Mark McCall has made only one change to the starting XV that convincingly beat Bath last weekend, with Kelly Brown replacing Ernst Joubert in the back row.
Brown starts his first game for Saracens this season, after recovering from an ankle injury – the Scot takes his place in the back-row at Blindside Flanker alongside Jacques Burger, and Bill Vunipola at No.8.
George Kruis keeps his place at lock, whilst in the backs the back-line remained unchanged from the seven that played against Bath.
Jackson Wray is back in the mix, named as a substitute as Nick Auterac, Michael Tagicaikibau and Jack Wilson all come into the match-day 23 for the first time this season.
Team to face Harlequins;
1. M. Vunipola, 2. Brits, 3. Stevens, 4. Borthwick ©, 5. Kruis, 6. Brown, 7. Burger, 8. B. Vunipola; 9. Wigglesworth, 10. Farrell; 11. Strettle, 12. Taylor, 13. Wyles, 14. Ashton; 15. Goode
16. George, 17. Auterac, 18. Johnston, 19.Hargreaves, 20. Wray, 21. De Kock, 22. Tagicakibau, 23. Wilson